研發(fā)創(chuàng )新
R&d innovation
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ScRNA-seq unveils the functional characteristics of glioma-associated macrophages and the regulatory effects of chlorogenic acid on the immune microenvironment-a study based on mouse models and clinical practice
ScRNA-seq unveils the functional characteristics of glioma-associated macrophages and the regulatory effects of chlorogenic acid on the immune microenvironment-a study based on mouse models and clinical practice2025.01.10這篇論文研究了綠原酸（Chlorogenic Acid, CHA）對膠質(zhì)瘤（Glioma）免疫微環(huán)境的調節作用，以及其在小鼠模型和臨床實(shí)踐中的潛在應用。研究通過(guò)單細胞RNA測序（scRNA-seq）揭示了膠質(zhì)瘤相關(guān)巨噬細胞（Tumor-Associated Macrophages, TAMs）的亞群和功能特征，并探討了CHA對免疫微環(huán)境的調節作用及其臨床應用潛力。 -
Target fishing and mechanistic insights of the natural anticancer drug candidate chlorogenic acid
Target fishing and mechanistic insights of the natural anticancer drug candidate chlorogenic acid2024.07.10該研究通過(guò)開(kāi)發(fā)綠原酸光親和探針結合前沿的化學(xué)生物學(xué)技術(shù)，深入揭示了線(xiàn)粒體乙酰輔酶A乙?；D移酶1（ACAT1）作為綠原酸關(guān)鍵靶蛋白的重要角色。研究團隊綜合運用了組學(xué)、分子生物學(xué)、細胞生物學(xué)和結構生物學(xué)等多學(xué)科技術(shù)手段，對綠原酸與ACAT1的相互作用機制進(jìn)行了全面而系統地研究，為綠原酸在癌癥治療領(lǐng)域的臨床應用奠定了理論與實(shí)驗基礎。
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ACAT1 Induces the Differentiation of Glioblastoma Cells by Rewiring Choline Metabolism
ACAT1 Induces the Differentiation of Glioblastoma Cells by Rewiring Choline Metabolism2024.01.05綠原酸作為一種天然小分子化合物，通過(guò)抑制ACAT1的磷酸化，能夠有效誘導GBM細胞的分化，具有作為膠質(zhì)瘤治療藥物的潛力。
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Cancer Differentiation Inducer Chlorogenic Acid Suppresses PD-L1 Expression and Boosts Antitumor Immunity of PD-1 Antibody
Cancer Differentiation Inducer Chlorogenic Acid Suppresses PD-L1 Expression and Boosts Antitumor Immunity of PD-1 Antibody2024.01.04該研究聚焦于綠原酸（CHA）在癌癥免疫治療中的作用，發(fā)現CHA可作為小分子免疫檢查點(diǎn)抑制劑，通過(guò)誘導分化，抑制癌細胞上PD-L1的表達，有效促進(jìn)腫瘤中浸潤T細胞，增強抗PD-1抗體的抗腫瘤效果，有望成為與抗PD-1抗體聯(lián)合使用、增強抗癌免疫治療效果的有潛力藥物。
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Chlorogenic Acid Induced Neuroblastoma Cells Differentiation via the ACAT1-TPK1-PDH Pathway
Chlorogenic Acid Induced Neuroblastoma Cells Differentiation via the ACAT1-TPK1-PDH Pathway2023.06.14本研究揭示了綠原酸通過(guò)ACAT1-TPK1-PDH途徑誘導神經(jīng)母細胞瘤細胞分化的機制。研究發(fā)現，綠原酸在體內外均能誘導神經(jīng)母細胞瘤細胞系（如Be(2)-M17和SH-SY5Y）的分化。其機制涉及抑制線(xiàn)粒體乙酰輔酶A乙酰轉移酶（ACAT1）的活性。ACAT1的敲低或抑制可上調硫胺素焦磷酸激酶1（TPK1）的表達，進(jìn)而激活硫胺素代謝途徑，增強丙酮酸脫氫酶（PDH）的活性。
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Phase I study of chlorogenic acid injection for recurrent high-grade glioma with long-term follow-up
Phase I study of chlorogenic acid injection for recurrent high-grade glioma with long-term follow-up2023.05.20本文是一項關(guān)于注射用綠原酸治療復發(fā)性高級別膠質(zhì)瘤的I期臨床研究，旨在評估其安全性、耐受性、藥代動(dòng)力學(xué)特征及初步抗腫瘤活性。研究方法本研究為非隨機、開(kāi)放標簽、劑量遞增的I期臨床試驗，共納入26例復發(fā)性高級別膠質(zhì)瘤患者，接受不同劑量（2-5.5mg/kg）的綠原酸肌肉注射，并進(jìn)行長(cháng)達5年的隨訪(fǎng)。研究結果顯示綠原酸耐受性良好，最大耐受劑量為5.5mg/kg。